[Download] "Screening for Primary Aldosteronism: Implications of an Increased Plasma Aldosterone/Renin Ratio (Endocrinology and Metabolism)" by Clinical Chemistry * eBook PDF Kindle ePub Free
eBook details
- Title: Screening for Primary Aldosteronism: Implications of an Increased Plasma Aldosterone/Renin Ratio (Endocrinology and Metabolism)
- Author : Clinical Chemistry
- Release Date : January 01, 2002
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 205 KB
Description
Background: The value of the ratio of plasma aldosterone concentration (aldosterone) to plasma renin activity (renin) to identify patients at risk for primary aldosteronism is controversial. We determined the sensitivity, specificity, and predictive value of the ratio to identify combinations of renin and aldosterone compatible with primary aldosteronism. Methods: The ratio was calculated in 505 adults with essential hypertension (143 black women, 82 black men, 122 white women, and 158 white men). We used a conventional cutpoint for an increased ratio (i.e., 20 mL/dL * h). The primary combination of renin and aldosterone considered compatible with primary aldosteronism was increased aldosterone for the concomitant renin, defined as aldosterone in the highest quartile predicted by linear regression on renin. Renin was considered low if it was in the lowest quartile of the sample distribution.
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